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Synlett
DOI: 10.1055/a-2605-1414
DOI: 10.1055/a-2605-1414
Letter
Nickel-Catalyzed Enantioselective Hydroboration of Styrenes
Supported by: Fundamental Research Funds of Zhejiang Sci-Tech University 23062110-Y, 22062143-Y
Supported by: Zhejiang Province Post-Doctoral Research Project Selected Funding ZJ2023033
Supported by: China Postdoctoral Science Foundation 2024M762339
Supported by: Natural Science Foundation of Zhejiang Province LQ23B020009
Funding Information This work was financially supported by the Natural Science Foundation of Zhejiang Province (Grants LQ23B020009), the Zhejiang Province Post-Doctoral Research Project Selected Funding (Grant ZJ2023033), China Postdoctoral Science Foundation (Grant 2024M762339), and Fundamental Research Funds of Zhejiang Sci-Tech University (Grants 23062110-Y, 22062143-Y).
Abstract
Herein, we established a Ni-catalyzed enantioselective hydroboration process of styrene derivatives using a chiral Box ligand with B2pin2 as the hydroboration reagent. This approach demonstrates the feasibility of stereoselective transmetalation of a benzylic carbon–nickel bond using B2pin2. The sought-after stable borated product can be achieved with elevated regio- and enantioselectivity under mild circumstances.
Publication History
Received: 09 March 2025
Accepted after revision: 09 May 2025
Accepted Manuscript online:
09 May 2025
Article published online:
23 July 2025
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